Indications

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone. Read more

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How to Inject ENBREL

You have several options for taking ENBREL. You and your doctor will decide which one is right for you.

Remember, the following information is intended to provide you with an overview and basic information about each injection device for ENBREL. They do not replace the Instructions for Use. That’s why it is extremely important that you thoroughly review the Instructions for Use for any device that you plan to use. Those instructions cover everything you need to know about how to use ENBREL.

As always, please contact your healthcare provider if you have any questions.

SureClick® autoinjector

The SureClick® autoinjector allows you to take your ENBREL with the press of a button. Plus it’s designed to make a clicking noise when you start and finish your injection.

Please note: this device is not for use in children (ages 4-17 years) with chronic moderate to severe plaque psoriasis or children with pJIA or JPsA who weigh less than 138 pounds (63 kg).

For more information on the SureClick® autoinjector

INSTRUCTION FOR USE
READ VIDEO TRANSCRIPT

AutoTouch® autoinjector

READ VIDEO TRANSCRIPT
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Need troubleshooting tips for your AutoTouch® autoinjector?

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WATCH VIDEOS

Need troubleshooting tips for your AutoTouch® autoinjector?

WATCH VIDEOS

The AutoTouch® autoinjector helps you track your injection from start to finish with light and sounds cues.

Please note: this device is not for use in children (ages 4-17 years) with chronic moderate to severe plaque psoriasis or children with pJIA or JPsA who weigh less than 138 pounds (63 kg).

For more information on the AutoTouch® autoinjector

INSTRUCTION FOR USE

Prefilled syringe

Prefilled syringes are manually injected, which means you control the rate of injection. Each one contains a single dose.

Please note: the 25-mg syringe is not for use in children (ages 4-17 years) with chronic moderate to severe plaque psoriasis or children with pJIA or JPsA who weigh less than 68 pounds (31 kg).

Please note: the 50-mg syringe is not for use in children (ages 4-17 years) with chronic moderate to severe plaque psoriasis or children with pJIA or JPsA who weigh less than 138 pounds (63 kg).

For more information on the Prefilled syringe

INSTRUCTION FOR USE
READ VIDEO TRANSCRIPT

Single-dose vial

The single-dose vial is the only option available for children (ages 4-17 years) with chronic moderate to severe plaque psoriasis and children with pJIA or JPsA who weigh less than 68 pounds (31 kg).

Please note: syringes and needles are not supplied with the single-dose vial, though they are required for injection. They may require a separate prescription from your doctor. We recommend the following:

  • Syringes: 1-mL Luer lock
  • Withdrawal needles: 22-gauge, sterile needles with Luer-lock connection. Length: 1.5 inches
  • Injection needles: 27-gauge, sterile needles with Luer-lock connection. Length: .5 inch

Two vials may be required to administer the total prescribed dose. Use the same syringe for each vial. The vial does not contain preservatives; therefore, discard unused portions.

For more information on the single-dose vial

INSTRUCTION FOR USE
READ VIDEO TRANSCRIPT

Frequently Asked Questions

Here are some frequently asked questions about how to take ENBREL.

  • What’s the typical ENBREL dosage for adults?

    Your doctor will recommend the best dose and dosing schedule for you. Always follow their instructions. But in general, the recommended dosage of ENBREL is as follows:

    CONDITION

    RECOMMENDED DOSING

    Adult patients with moderate to severe RA, PsA, or AS

    50 mg, once weekly

    Adult patients with moderate to severe PsO

    For the first 3 months: 50 mg, twice weekly After the first 3 months: 50 mg, once weekly

    CONDITION

    Adult patients with moderate to severe RA, PsA, or AS

    Adult patients with moderate to severe PsO

    RECOMMENDED DOSING

    50 mg, once weekly

    For the first 3 months: 50 mg, twice weekly After the first 3 months: 50 mg, once weekly

    COLLAPSE

  • What’s the typical ENBREL dosage for children?

    Your doctor will recommend the best dose and dosing schedule for your child. Always follow their instructions. But in general, the recommended dosage of ENBREL is based on weight, as follows:

    CONDITION

    RECOMMENDED DOSING

    Pediatric patients (ages 2 years and older) with
    JPsA or moderate to severe pJIA

    For patients weighing 138 lb (63 kg) or more: 50 mg, once weekly For patients weighing less than 138 lb (63 kg):
    0.8 mg per kg, once weekly—with a maximum dose of 50 mg per week

    Pediatric patients (ages 4 years and older)
    with moderate to severe PsO

    For patients weighing 138 lb (63 kg) or more: 50 mg, once weekly For patients weighing less than 138 lb (63 kg):
    0.8 mg per kg, once weekly—with a maximum dose of 50 mg per week

    CONDITION

    Pediatric patients (ages 2 years and older) with
    JPsA or moderate to severe pJIA

    Pediatric patients (ages 4 years and older)
    with moderate to severe PsO

    RECOMMENDED DOSING

    For patients weighing 138 lb (63 kg) or more: 50 mg, once weekly For patients weighing less than 138 lb (63 kg): 0.8 mg per kg, once weekly—with a maximum dose of 50 mg per week

    For patients weighing 138 lb (63 kg) or more: 50 mg, once weekly For patients weighing less than 138 lb (63 kg): 0.8 mg per kg, once weekly—with a maximum dose of 50 mg per week

    COLLAPSE

  • I missed a dose. What should I do?

    Call your doctor to find out when you should take your next dose. It’s important to take ENBREL as scheduled.

    COLLAPSE

  • How do I inject ENBREL, and who can I contact if I have questions regarding my injection?

    Your doctor or nurse will train you on how to inject ENBREL. Remember to thoroughly review the Instructions for Use for any device that comes with your ENBREL medication you plan to use before injecting with ENBREL. Those instructions cover everything you need to know about how to use ENBREL. You can also watch the injection demonstration videos above to supplement the information you get from your doctor or nurse.

    For one-on-one supplemental injection support, Amgen Nurse Partners* can help you get more comfortable injecting on your own. They offer support when it’s most convenient for you: via video chat or over the phone. Click here to enroll in the Amgen® Nurse Partner program. You can call 1-888-4ENBREL (1-888-436-2735) Monday - Friday, 8AM - 8PM ET, when you’re ready to speak with an Amgen Nurse Partner.

    *Amgen Nurse Partners are only available to patients that are prescribed certain Amgen products. They are not part of your treatment team and do not provide medical advice, nursing, or case management services. Amgen Nurse Partners will not inject patients with Amgen medications. Patients should always consult their healthcare provider regarding medical decisions or treatment concerns.

    COLLAPSE

  • Where on the body do I inject ENBREL?

    You can inject ENBREL on the front of the middle thigh, or on your stomach (except for the 2-inch area around your belly button). If someone else is giving you the injection, they can do so on the outer area of your upper arm. Choose a different site each time you give yourself an injection. If you need to use the same injection site, just make sure it is not on the same spot that you used last time. Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid injecting into areas with scars or stretch marks.

    Skin reactions around the injection area, such as redness, pain, swelling, itching, or bruising have happened. On average, these symptoms go away within 3 to 5 days. If you have any of these reactions and they don’t go away or they get worse, call your doctor.

    COLLAPSE

  • Can I let ENBREL warm up before injecting?

    Injecting cold ENBREL can be uncomfortable. To help make it more comfortable, take ENBREL out of the refrigerator and wait for it to reach room temperature (which should take at least 30 minutes before injecting). Do not remove the white cap from the ENBREL SureClick® autoinjector until you are ready to inject. Do not warm it in a microwave or in hot water, and do not remove the needle cover while you wait. Keep these guidelines in mind:

    • In general, store ENBREL in the refrigerator at 36°F to 46°F (2°C to 8°C)
    • You may store the ENBREL prefilled syringe, SureClick® autoinjector, ENBREL Mini® single-dose prefilled cartridge, or the ENBREL single-dose vial at room temperature between 68°F and 77°F (20°C and 25°C) for up to 30 days
    • Once ENBREL has reached room temperature, do not put it back in the refrigerator
    • Throw away ENBREL that has been stored at room temperature after 30 days
    • For more on how to store your ENBREL at room temperature, click here.
    COLLAPSE

  • What if my skin around the ENBREL injection site gets red and itchy?

    Sometimes this can happen. Some common ENBREL injection site reactions include redness, pain, swelling, itching, or bruising. However, these symptoms tend to go away within 3 to 5 days. If they don’t go away (or if they get worse), call your doctor.

    COLLAPSE

  • What should I do if the needle is bent, or the injection device is damaged?

    If a needle or an injection device is damaged in any way, don’t try to use it or fix it. Don’t throw it away either. Call 1-888-4ENBREL (1-888-436-2735), 8 AM–8 PM ET, Monday through Friday, and we will help you.

    COLLAPSE

  • What should I do with my needles, syringes, vials, SureClick® autoinjectors, or ENBREL Mini® single-dose prefilled
    cartridges after injecting?

    Right after injecting, discard your needle, syringe, vials, SureClick® autoinjector, or ENBREL Mini® single-dose prefilled cartridge in a puncture-resistant sharps disposal container. You can buy one at your local pharmacy. Do not recap or reuse any of the items listed above.

    COLLAPSE

Prescription Enbrel® (etanercept) is taken (given) by injection.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers, some resulting in death, reported in children and teenagers who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.

Before starting ENBREL, tell your healthcare provider if you:

  • Have any existing medical conditions
  • Are taking any medicines, including herbals
  • Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay
  • Have any open cuts or sores
  • Have diabetes, HIV, or a weak immune system
  • Have TB or have been in close contact with someone who has had TB
  • Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure
  • Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider
  • Have or have had hepatitis B
  • Have or have had heart failure
  • Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
  • Use the medicine Kineret (anakinra), Orencia (abatacept), or Cytoxan (cyclophosphamide)
  • Are taking anti-diabetic medicines
  • Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
  • Are scheduled to have surgery
  • Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have been around someone with chicken pox

What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.

Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).

In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

INDICATIONS

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (pJIA) in children 2 years of age or older.

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in adult patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.

ENBREL is indicated for active juvenile psoriatic arthritis (JPsA) in children 2 years of age or older.

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years of age or older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).

Prescription Enbrel® (etanercept) is taken (given) by injection.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections.